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M&I Newsletter
July 2023

Honors, Awards, and Recognitions...
 
Congratulations to the following Jakubzick Lab member:
  • Kavita Rawat was awarded the Career Advancement and Research Excellence Support (CARES) grant from FASEB.

Congratulations to the following O'Toole Lab members:
  • Fabrice Jean-Pierre and Chris Kesthely were selected for talks at the Canadian Society of Microbiologists (CSM 2023).
  • Chris Kesthely was selected for an abstract talk at a FASEB meeting.

Congratulations to the following Curiel Lab members:
  • Carlos Ontiveros May 2023 AAI Minority Scientist Award - 2023 Annual AAI Meeting
  • Carlos Ontiveros June 2023 Scholarship from National Hispanic Scholarship Fund
  • Carlos Ontiveros Oral Presentation at AAI May 2023 "Melanocyte PDL1 promotes early tumor progression in a novel autochthonous NRAS-mutant melanoma model"
  • Clare Murray Oral Presentation at AAI May 2023 "Pharmacologic Tumor PDL1 Depletion as a Novel Approach to Overcome Treatment Resistance"
 
Congratulations to the following Leib Lab members:
  • Paige Canova, Fiona McEnany, Matt Slein and Roberto Alers-Velazquez who all gave talks at the June 2023 American Society for Virology meeting.
Congratulations on new funding...
 
  • Tyler Curiel March 2023 First Prize Dartmouth Accelerator for Innovations in Cancer "Blocking PDL2 as novel cancer immunotherapy" $150,000
  • Hitchcock Foundation Pilot Grant- Alix Howell "Immunomodulatory Effects of microRNAs Present in Breast Milk Extracellular Vesicles:" This project will define the extent to which certain microRNAs present in breast milk extracellular vesicles (EVs) can suppress inflammation, especially in the gut.
  • Robert Cramer, R01 competing renewal, "Evolution of Aspergillus fumigatus virulence" starts 07/11/23
  • Roberto Alers-Velazquez, Burroughs Wellcome Postdoctoral Diversity Enrichment Program, "Mechanism for HSV-1 neuroimmune modulation and neurological sequelae on neonates" starts 9/1/23
Recent Publications

Mrs4 loss of function in fungi during adaptation to the cystic fibrosis lung
Murante D, Demers EG, Kurbessoian T, Ruzic M, Ashare A, Stajich JE, Hogan DA
mBio. 2023 Jul 11;e0117123. doi: 10.1128/mbio.01171-23. Online ahead of print.
PMID: 37432019


Gp05, a Prophage-Encoded Virulence Factor, Contributes to Persistent Methicillin-Resistant Staphylococcus aureus Endovascular Infection.
Li Y, Zhu F, Manna AC, Chen L, Jiang J, Hong JI, Proctor RA, Bayer AS, Cheung AL, Xiong YQ
Microbiol Spectr. 2023 Jun 26;:e0060023. doi: 10.1128/spectrum.00600-23. Epub 2023 Jun 26.
PMID: 37358448

Channeling antigens to CD8(+) T cells.
Rawat K, Jakubzick CV
Science. 2023 Jun 23;380(6651):1218-1219. doi: 10.1126/science.adi5711. Epub 2023 Jun 22.
PMID: 37347866

The Potency of Cowpea Mosaic Virus Particles for Cancer In Situ Vaccination Is Unaffected by the Specific Encapsidated Viral RNA.
Jung E, Chung YH, Mao C, Fiering SN, Steinmetz NF
Mol Pharm. 2023 Jul 3;20(7):3589-3597. doi: 10.1021/acs.molpharmaceut.3c00214. Epub 2023 Jun 9.
PMID: 37294891

In host evolution of Exophiala dermatitidis in cystic fibrosis lung micro-environment.
Kurbessoian T, Murante D, Crocker A, Hogan DA, Stajich JE
G3 (Bethesda). 2023 Jun 9; pii: jkad126. doi: 10.1093/g3journal/jkad126. Epub 2023 Jun 9.
PMID: 37293838


Development of the intestinal microbiome in cystic fibrosis in early life
Price CE, Hampton TH, Valls RA, Barrack KE, O'Toole GA, Madan JC, Coker MO.
mSphere. 2023 Jul 5:e0004623. doi: 10.1128/msphere.00046-23. Epub ahead of print.
PMID: 37404016
 

Evidence for the Type IV Pilus Retraction Motor PilT as a Component of the Surface Sensing System in Pseudomonas aeruginosa.
Geiger CJ, O'Toole GA.

J Bacteriol. 2023 Jun 29:e0017923. doi: 10.1128/jb.00179-23. Epub ahead of print.
PMID: 37382531


Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer
Disis, M. L. Adams, S. F. Bajpai, J. Butler, M. O. Curiel, T. Dodt, S. A. Doherty, L. Emens, L. A. Friedman, C. F. Gatti-Mays, M. Geller, M. A. Jazaeri, A. John, V. S. Kurnit, K. C. Liao, J. B. Mahdi, H. Mills, A. Zsiros, E. Odunsi, K. J Immunother Cancer 2023;11(6)
DOI 10.1136/jitc-2022-006624.
PMID: 37295818


PlmCas12e (CasX2) Cleavage of CCR5: Impact of Guide RNA Spacer Length and PAM Sequence on Cleavage Activity.
Armstrong, DA, Hudson, TR, Hodge, CA, Hampton, TH, Howell, AL, Hayden, MS.
RNA Biol.2023 Jan;20(1):296-305. DOI: 10.1080/15476286.2023.2221510.
PMID: 37287312

Alumni news....  
  • Kurt Dahlstrom, Assistant Professor, University of Georgia, received a R35GM150797 award, Bacterial partners as a mode of fungal resistance to antimicrobial compounds. Kurt was a graduate student in Dr. O'Toole's lab.
  • Jarrod Smith, Postdoc, University of Oregon, received a K99DK137017, Understanding the molecular mechanisms of Akkermansia glycan-binding adhesins in shaping microbial communities and balancing intestinal inflammation in response to host signals. Jarrod was a graduate student in Dr. O'Toole's lab.
  • Stefan Katharios-Lanwermeyer, Postdoc, National Cancer Institute, received a PRAT (NIH intramural) fellowship award.  Stefan was a graduate student in Dr. O'Toole's lab.
ADMINISTRATIVE UPDATES

As always, please send backup and inquiries to Microbiology.and.Immunology@dartmouth.edu  


 

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